Which result from the prenatal Quad Screen suggests the presence of Trisomy 21?

The result from the prenatal Quad Screen indicative of Trisomy 21, also known as Down syndrome, is characterized by elevated levels of Inhibin A, decreased alpha-fetoprotein (AFP), elevated human chorionic gonadotropin (hCG), and decreased estriol (uE3).

In the context of Trisomy 21, the specific patterns of these markers have clinical relevance. An increase in Inhibin A is frequently associated with Down syndrome. The decrease in AFP suggests reduced production from the fetal liver, which often occurs in the case of Trisomy 21. Meanwhile, the elevation of hCG and the decrease in uE3 further support the likelihood of aneuploidy, particularly Trisomy 21.

This combination of markers (Inhibin A elevated, AFP decreased, hCG elevated, and uE3 decreased) collectively points toward the increased risk of the fetus having Down syndrome. Therefore, it is critical for healthcare providers to understand these specific values when interpreting Quad Screen results, as they guide further diagnostic testing and counseling.