Which following outcome indicates a positive screening result for coagulopathy?

A positive screening result for coagulopathy is indicated by a history of heavy periods, also known as menorrhagia, since menarche. This symptom is significant because it suggests that the body may have difficulty properly coagulating blood or managing bleeding, which can be characteristic of various bleeding disorders, such as von Willebrand disease or hemophilia.

Menorrhagia can lead to severe anemia and other complications if left unaddressed, prompting further investigation into potential underlying coagulation issues. The menstrual cycle's patterns — particularly heavy or prolonged bleeding — serve as critical indicators for healthcare providers to assess the potential for coagulopathy in women.

Other options do not directly correlate with coagulopathy. A history of irregular cycles could indicate other menstrual disorders but is not specific to bleeding disorders. A family history of heart failure is more related to cardiovascular issues, while frequent headaches might indicate migraines or other neurologic conditions, neither of which are inherently linked to coagulopathy.