What is the most common cause of new-onset secondary amenorrhea?

The most common cause of new-onset secondary amenorrhea is pregnancy. Secondary amenorrhea is defined as the absence of menstruation for three cycles or more in a woman who has previously menstruated. In many cases, a missed period is the first sign of pregnancy. It is essential for clinicians to consider pregnancy as a primary possibility when evaluating any woman of childbearing age presenting with amenorrhea.

Confirmation of pregnancy typically involves qualitative or quantitative hCG testing. Given the prevalence of unplanned pregnancies, especially in younger women, this condition frequently underlies cases of secondary amenorrhea. Understanding this context is vital for a holistic approach to women's health.

While conditions like polycystic ovarian syndrome, pituitary tumors, and anovulation may also contribute to secondary amenorrhea, they are not as common a cause as pregnancy. Recognizing these nuances allows healthcare providers to conduct more targeted assessments and interventions.